Investigations of Curcumin and Resveratrol on Neurite Outgrowth: Perspectives on Spinal Muscular Atrophy

Figure 1

Neurite outgrowth analysis after curcumin and resveratrol treatments in wt PC12 cells. (a) Examples of the untreated, curcumin and resveratrol treated PC12 cells at 3 and 7 days of differentiation. Scale bar; 100 μm (b) quantitative measurements of the neurite lengths at 3 and 7 days of differentiation after 500 nM curcumin treatment, two-way ANOVA (𝑃=0.22), two group comparisons with Mann-Whitney 𝑈-test (^∗∗∗∗𝑃<0.0001). (c) Neurite length measurements at 3 and 7 days of differentiation after 5 μM resveratrol treatment, two-way ANOVA (𝑃=0.003) with Bonferroni posttest (^∗∗∗∗𝑃<0.0001). Data are presented as means ± standard error (SE), 𝑛=3, n.s: non significant.