Abnormal Cardiac Autonomic Regulation in Mice Lacking ASIC3
Figure 2
Isoproterenol-induced tachycardia (a) ECG of RR interval showing tachycardia from both genotypes 5 min after isoproterenol injection (1.5 mg/kg given intraperitoneally) on radiotelemetry. Asic3 +/+ mice showed higher HR than Asic3 −/− mice in most periods of tachycardia (*). Asic3 −/− mice needed a longer time to slow down the HR to baseline than Asic3 +/+ mice. (b) Mean HR during isoproterenol-induced tachycardia is significantly different between genotypes; tachycardia defined as RR interval less than 90 ms; Asic3 −/− mice 84.7 ± 0.1 ms versus Asic3 +/+ mice 82.4 ± 0.1 ms. (c) Mean duration of isoproterenol-induced tachycardia of Asic3 −/− mice 82.9 ± 5.1 min versus Asic3 +/+ mice 59.7 ± 1.7 min (**, ***; Asic3 +/+ mice; Asic3 −/− mice).
