Cortisol Is an Associated-Risk Factor of Brain Dysfunction in Patients with Severe Sepsis and Septic Shock
Table 2
Biomarkers levels, ICU clinical evolution, and outcome.
All patients ()
Non-brain dysfunction ()
Brain dysfunction ()
Cortisol admission (nmol/L)
0.013
Cortisol day 4 (nmol/L)
0.441
S100B admission (g/L)
0.13 (0.07, 0.28)
0.97 (0.51, 0.18)
0.13 (0.06, 0.49)
0.188
S100B day 4 (g/L)
0.13 (0.06, 0.2)
0.08 (0.04, 0.13)
0.12 (0.08, 0.24)
0.038
Mechanical ventilation, days
0.109
Inotropics length, days
0.191
SOFA score for the first 4 days
0.006
Sedation, days
0.315
Midazolam, (%)
80 (62)
12 (57)
68 (64)
0.579
Fentanyl, (%)
75 (59)
13 (62)
62 (58)
0.736
Propofol, (%)
48 (37)
9 (43)
41 (38)
0.696
Nosocomial infection, (%)
67 (52)
5 (24)
62 (58)
<0.01
Shock recurrence, (%)
37 (29)
1 (5)
36 (34)
<0.01
CINM, (%)
64 (50)
4 (19)
60 (56)
0.003
ICU mortality, (%)
69 (54)
3 (14)
66 (62)
<0.01
Continuous variables were represented as mean values ± standard deviation. S100B levels were represented as median (interquartile) due to skewed values. CNIM: critical illness neuromyopathy.
