A Derived Network-Based Interferon-Related Signature of Human Macrophages Responding to Mycobacterium tuberculosis

Table 3

GSEA using transcriptome data of whole blood from human PTB patients undergoing clinical therapy.

Group comparison^1	THP1r2Mtb-induced			TMtb-iNet			TMtb-iEx
	NES^2	FDR^3	Correlation^3	NES^2	FDR^3	Correlation^3	NES^2	FDR^3	Correlation^3
PTB_0m versus HC	2.95	0.000	Positive	3.29	0.000	Positive	2.31	0.000	Positive
PTB_2m versus HC	2.62	0.000	Positive	2.83	0.000	Positive	2.43	0.000	Positive
PTB_12m versus HC	1.43	0.000	Positive	1.15	0.182	Null	1.49	0.005	Positive
PTB_2m versus PTB_0m	−2.08	0.000	Negative	−2.36	0.000	Negative	−1.53	0.000	Negative
PTB_12m versus PTB_0m	−2.96	0.000	Negative	−3.16	0.000	Negative	−2.29	0.000	Negative

¹PTB_0m: PTB patients before drug treatment; PTB_2m: 2 months after initiation of drug treatment; PTB_12m: 12 months after initiation of drug treatment [2].
^2,3The same as Table 1.