A Derived Network-Based Interferon-Related Signature of Human Macrophages Responding to Mycobacterium tuberculosis

Table 6

GSEA using transcriptome data of CD4⁺ or CD8⁺ T cells from AIDS patients.

Group comparison^1	THP1r2Mtb-induced			TMtb-iNet			TMtb-iEx
	NES^2	FDR^3	Relevance^3	NES^2	FDR^3	Correlation^3	NES^2	FDR^3	Correlation^3
CD4_acute HIV versus CD4_HC	2.61	0.000	Positive	2.82	0.000	Positive	1.75	0.000	Positive
CD4_chronic HIV versus CD4_HC	3.06	0.000	Positive	3.35	0.000	Positive	1.59	0.006	Positive
CD4_nonprogressor HIV versus CD4_HC	−0.70	1.000	Null	−0.66	1.000	Null	−0.62	1.000	Null
CD8_acute HIV versus CD8_HC	2.59	0.000	Positive	2.78	0.000	Positive	1.46	0.013	Positive
CD8_chronic HIV versus CD8_HC	2.70	0.000	Positive	3.34	0.000	Positive	−0.75	0.912	Null
CD8_nonprogressor HIV versus CD8_HC	1.73	0.000	Positive	1.87	0.000	Positive	1.13	0.127	Null

¹Acute HIV: early infection; chronic HIV: chronic, no treatment; nonprogressor: long-term nonprogressor.
^2,3The same as Table 1.