A Rat Model of Thrombosis in Common Carotid Artery Induced by Implantable Wireless Light-Emitting Diode Device
Figure 6
Histologic and immunohistochemical staining of arterial thrombosis 3 days after intermittent 4.5 mW/cm2 LED irradiation for 2 h first, shut off for 30 min, then for another 2 h. Microphotographs of hematoxylin-eosin (a and b) and PECAM-1 (c and d) staining at the left common carotid artery (CCA) with LED irradiation and right CCA without LED irradiation. Thrombus formation can be seen in the lumen of the LED-irradiated vessel (a and c). The endothelium of the LED-irradiated vessel is injured and there is platelet adhesion (a, arrowheads). PECAM-1 expression in injured and noninjured vessels is shown in c and d. Except for the platelet adhesion, the endothelial cells are injured and discontinued (c, arrowheads). However, the endothelial cells in the CCA without LED irradiation are intact (d). T: thrombus. Original magnification 200x. Bar = 200 μm.
