The Interrelationship between Leukotriene B4 and Leukotriene-A4-Hydrolase in Collagen/Adjuvant-Induced Arthritis in Rats

Table 1

LTB4 (ng/mL) in plasma, synovial fluid (SF), soluble (SO), and solubilized membrane-bound (MB) fractions from synovial tissue (ST) and peripheral blood mononuclear cells (PBMCs) from control, CIA-arthritic, and CIA-resistant rats.

Samples	Control	CIA-arthritic	CIA-resistant	ANOVA
PLASMA	0.1454±0.0006^a	0.2119±0.0208^b	0.2130±0.0125^ab	𝑃=0.0223
SF	0.0283±0.0037^a	0.0552±0.0061^b	0.0538±0.0086^b	𝑃=0.0214
SO-ST	0.4038±0.0072^a	0.1452±0.0262^b	0.1836±0.0560^b	𝑃=0.0090
MB-ST	0.0954±0.0006^a	0.1581±0.0039^b	0.1194±0.0006^c	𝑃=0.0007
SO-PBMCs	0.7163±0.0141^a	0.6975±0.0168^a	0.4368±0.0139^b	𝑃<0.0001
MB-PBMCs	0.3045±0.0636^a	0.0555±0.0050^b	0.0684±0.0021^b	𝑃=0.0051

Values ​ ​are mean ± SEM. Number of animals = 3, values ​ ​of each animal measured in duplicate. Student-Newman-Keuls, 𝑃<0.05: comparison among control versus CIA-arthritic versus CIA-resistant in the same row (different letters indicate significant difference).