The Interrelationship between Leukotriene B4 and Leukotriene-A4-Hydrolase in Collagen/Adjuvant-Induced Arthritis in Rats
LTA4H activity (U) in the plasma, synovial fluid (SF), soluble (SO), and solubilized membrane-bound (MB) fractions of synovial tissue (ST) and peripheral blood mononuclear cells (PBMCs) from control, CIA-arthritic, and CIA-resistant rats.
Values are mean ± SEM. U = LTA4H unit = LTA4H activity in 1 mL sample that catalyzes the formation of 1 picomole of LTB4 per minute. Number of , values of each animal measured in duplicate. Student-Newman-Keuls, : comparison among control versus CIA-arthritic versus CIA-resistant in the same row (different letters indicate significant difference).