BioMed Research International

Research Article

The Interrelationship between Leukotriene B4 and Leukotriene-A4-Hydrolase in Collagen/Adjuvant-Induced Arthritis in Rats

Table 3

Changes in LTB4 and LTA4H in CIA-arthritic and CIA-resistant relatively to healthy control rats.
SamplesLTB4LTA4H activity
CIA-arthritic CIA-resistantCIA-arthritic CIA-resistant
Plasma
Synovial fluid
Soluble fraction from synovial tissue
Solubilized membrane-bound fraction from synovial tissue
Soluble fraction from PBMCs
Solubilized membrane-bound fraction from PBMCs
Endogenous LTB4 content and LTA4H activity assessed by EIA. ( ) no difference; ( ) decrease; ( ) increase.