BioMed Research International / 2014 / Article / Tab 3

Research Article

Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada

Table 3

Cytotoxic activity against human tumor cells of the essential oils from the M. indica var. Rosa and M. indica var. Espada.

Essential oil aIC50 ( g/mL)
HT-29HEp-2NCI-292HL-60

EOMiR28.725.638.912.3
20.3–30.520.5–31.931.3–48.49.5–15.9

EOMiE 9.26.214.53.6
6.0–14.04.4–8.611.4–18.42.8–4.8

Terpinolene16.713.717.428.8
13.0–21.611.5–16.314.8–19.625.6–32.3

-Pinene10.311.011.811.8
8.7–12.27.7–15.69.1–13.510.0–14.0

-Pinene6.66.37.510.5
5.8–7.55.0–8.05.1–11.09.1–12.0

-3-Carene45.535.042.663.1
37.6–55.029.6–41.235.1–51.947.4–84.0

Terpinolene (74%) + -3-carene (6%)22.826.529.327.0
16.4–31.622.8–30.825.8–33.223.03–31.8

-Pinene (41%) + terpinolene (28%) + -pinene (11%)22.330.540.17.8
16.1–31.125.6–36.420.6–47.95.6–10.7

Terpinolene (74%) + -pinene (2%)39.435.030.4
36.0–43.127.7–44.3821.8–42.2

Doxorubicin0.40.70.010.2
0.3–0.50.2–1.40.004–0.30.01–0.2

Data are presented as IC50 values and 95% confidence intervals obtained by nonlinear regression for all cell lines from two independent experiments. Exposure time: 72 h. HEp-2: larynx carcinoma; NCI-H292: lung mucoepidermoid carcinoma; HT-29: colon adenocarcinoma; and HL-60: promyelocytic leukemia cells. Doxorubicin was used as a positive control. EOMiR: essential oil of M. indica var. Rosa; EOMiE: essential oil of M. indica var. Espada.