BioMed Research International / 2014 / Article / Tab 2

Review Article

Neurotoxicants Are in the Air: Convergence of Human, Animal, and In Vitro Studies on the Effects of Air Pollution on the Brain

Table 2

Genetic polymorphisms and the effects of diesel exhaust.

Gclm FADE

MDA (nmol/g)+/+5.7 ± 0.221.2 ± 0.3**
−/−5.2 ± 0.335.4 ± 0.3**,#
+/−9.7 ± 1.045.0 ± 0.7**,#

IL-1β (pg/mL)+/+12.7 ± 1.631.1 ± 6.1**
−/−7.2 ± 0.342.6 ± 2.4**
+/−18.6 ± 0.778.5 ± 4.3**,#

Male mice were exposed for 6 h to diesel exhaust (DE, 250–300 μg/m3) or filtered air (FA), and levels of malondialdehyde (MDA) and of interleukin 1-beta (IL-1β) were measured in the olfactory bulb, as markers of oxidative stress (lipid peroxidation) and neuroinflammation, respectively. Results are the mean (±SE) with . DE versus FA: ** ; versus or : # (two-way ANOVA followed by Bonferroni test for multiple comparisons) (Costa et al., unpublished results).

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