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BioMed Research International
Volume 2014, Article ID 736853, 10 pages
http://dx.doi.org/10.1155/2014/736853
Research Article

Blood Monocyte Subsets and Selected Cardiovascular Risk Markers in Rheumatoid Arthritis of Short Duration in relation to Disease Activity

1Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, University Hospital Śniadeckich Street 10, 31-531 Cracow, Poland
2Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, J. Dietl Hospital, Skarbowa Street 4, 31-121 Cracow, Poland
3Department of Rheumatology and Balneology, Jagiellonian University Medical College, University Hospital, Śniadeckich Street 10, 31-531 Cracow, Poland
4Division of Rheumatology, Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, University Hospital, Śniadeckich Street 10, 31-531 Cracow, Poland
52nd Department of Cardiology, Jagiellonian University Medical College, University Hospital, Kopernika Street 17, 31-501 Cracow, Poland

Received 28 March 2014; Revised 21 May 2014; Accepted 4 June 2014; Published 14 July 2014

Academic Editor: Grant Drummond

Copyright © 2014 Ewa Klimek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To evaluate blood monocyte subsets and functional monocyte properties in patients with rheumatoid arthritis (RA) of short duration in the context of cardiovascular (CV) risk and disease activity. Methods. We studied conventional markers of CV risk, intima media thickness (IMT), and blood monocyte subsets in 27 patients aged 41 ± 10 years with RA of short duration (median 12 months) and 22 healthy controls. The RA subjects were divided into low (DAS28: 2.6–5.1) and high (DAS28 > 5.1) disease activity. Results. RA patients exhibited increased levels of intermediate (CD14++CD16+) monocytes with decreased CD45RA expression compared to controls, increased counts of classical (CD14++CD16) monocytes, and decreased percentages of nonclassical (CD14+CD16++) monocytes. Patients with high disease activity had lower HLA DR expression on classical monocytes compared to low disease activity patients. There were no differences in monocyte subsets between subjects with DAS > 5.1 and DAS ≤ 5.1. There were no significant intergroup differences in IMT and the majority of classical CV risk factors. Conclusions. Patients with RA of short duration show alteration in peripheral blood monocyte subsets despite the fact that there is no evidence of subclinical atherosclerosis. Disease activity assessed with DAS28 was associated with impaired functional properties but not with a shift in monocyte subpopulations.