Blood Monocyte Subsets and Selected Cardiovascular Risk Markers in Rheumatoid Arthritis of Short Duration in relation to Disease Activity

Table 2

Monocyte subpopulations and their characteristics (total count, expression of HLA-DR, CD45RA, and 𝛽₂-integrins).

	RA (𝑛 = 27)	Control group (𝑛 = 22)	𝑃 value
	Mean (SD)	Mean (SD)
Monocytes total count (per 𝜇L of blood)	581.85 (220.24)	387.14 (110.15)	<0.001
CD14^++CD16^− classical monocytes
CD45RA, MFI	646.92 (182.17)	780.31 (293.99)	0.028
CD11c, MFI	1574.44 (609.28)	1286.57 (1072.39)	0.018
CD11b, MFI	1468.07 (841.15)	1707.85 (1816.07)	0.581
HLA-DR, MFI	7781.88 (3777.45)	6116.86 (2040.72)	0.072
CD14^++CD16^+ intermediate monocytes
CD45RA, MFI	696.59 (199.02)	1079.45 (594.60)	0.001
CD11c, MFI	2809.56 (918.04)	2877.95 (2235.30)	0.289
CD11b, MFI	1647.30 (932.19)	1937.57 (2182.40)	0.546
HLA-DR, MFI	26656.89 (8883.37)	30188.32 (7584.79)	0.146
CD14^+CD16^++ nonclassical monocytes
CD45RA, MFI	1942.93 (589.65)	3512.00 (2599.85)	0.029
CD11c, MFI	5038.59 (1981.75)	3532.43 (2599.87)	0.002
CD11b, MFI	770.96 (365.94)	855.19 (738.51)	0.692
HLA-DR, MFI	32300.37 (11860.56)	21097.32 (8487.21)	<0.001

Data are shown as means (SD). RA: rheumatoid arthritis; MFI: mean fluorescence intensity.