Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration

Figure 2

Chemokine receptors involved in migration of mouse and human DCs subsets. CCR7, CXCR4, CCR2, and CXCR5 are involved in subsets of cDCs migration from periphery tissues to draining LNs in both inflammation and steady-state. CCR5, ChemR23, CXCR3, and CCR7 are involved in migration of pDCs to LNs via hematogenous route. CCR2 is implicated in control of CD8α ⁺ DC to the spleen and relocalization of CD11c⁺ DC from the marginal zone to the T cell areas in spleen. CCR7, CXCR3, and CXCR4 are shown to be involved in pDCs migration from blood to spleen. CCR1, CCR2, CCR5, and CCR6 are involved in the recruitment of cDCs to different tissues in specific situations. CCR9 is shown to have a role in controlling the migration of pDC to the small intestine under both steady-state and inflammatory conditions. In other situations of inflammation or tumor, CXCR3, ChemR23, and CCR6 are implicated to be involved in pDCs migration to periphery tissues.