IL-33 Enhanced the Proliferation and Constitutive Production of IL-13 and IL-5 by Fibrocytes
Figure 3
IL-33 enhanced -smooth muscle actin expression and pro-MMP-9 activity. Fibrocytes were cultured with (solid lines) or without (broken lines) 10 ng/mL IL-33 for 72 h. Cells were stained with anti--SMA mAb (thick line) or isotype control IgG (thin line) (a). Relative expression of -SMA with and without IL-33 was determined by flow cytometry (b). The gelatinase activities of MMP-2 and MMP-9 were analyzed by gelatin zymography (c) and its relative expression was determined by densitometry (d). Results are means SEM (). .
