Review Article
Chondrogenic Differentiation of Human Adipose-Derived Stem Cells: A New Path in Articular Cartilage Defect Management?
Table 2
Expressed chondrogenic genes that are detectable at the different stages of differentiation over time (0 to 21 days) [
12].
| Chondrogenic differentiation | Expressed genes |
| Stage I | Collagen I, collagen VI | SOX 4 | BMP 2 |
| Stage II | COMP | HAPLN1 | Collagen XI | SOX 9 |
| Stage III | Matrilin 3 | Indian hedgehog | Homeobox 7 | Chondroadherin | WNT 11 |
| Stage IV | Aggrecan | Alkaline phosphatase | Collagen II, collagen IX, and collagen X | Fibromodulin | Osteocalcin | PTHrP |
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