Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates

Table 2

Immunoreactivity of TB MDR patients infected with Haarlem, LAM, and Tuscani Mtb lineages.

Patient data					Serology^2
Code	Sex	Age	SPT family^1	BAAR	Rv2241	Rv0407	Rv0009	Rv2624c
MDR18	F	24	Haarlem	+	+++	+++	+++	+
MDR5	F	35	Haarlem	−	+++	++	+	++
MDR19	M	28	Haarlem	+++	++	++	++	+
MDR11	M	28	Haarlem	+	+	+++	+	+
MDR2	F	44	Haarlem	+	+	+	++	+
MDR3	F	47	Haarlem	+	+	+	++	−
MDR14	F	35	Haarlem	−	−	+	−	−
MDR8	F	27	Tuscani	−	−	−	−	+
MDR10	F	23	LAM	+	+++	+++	+++	+++
MDR9	F	20	LAM	−	++	++	+++	+
MDR6	M	49	LAM	−	−	−	−	−
MDR12	M	28	LAM	−	−	−	−	−
MDR17	F	46	LAM	+++	−	−	−	−
MDR7	F	36	LAM	+	−	−	−	−
MDR13	M	24	LAM	+++	−	−	−	−
MDR4	F	40	LAM	+	−	−	−	−
MDR16	F	48	LAM	+++	−	−	−	−
MDR1	F	42	LAM	+	−	−	−	−

1For each MDR TB patient, genotype of infecting strain was assessed by standard spoligotyping methods [30, 31]. ²The relative OD values among seropositive samples are represented by “+++” (high OD values), “++” (mid OD values) and “+” (low OD values). Seronegative samples are indicated by “−” (OD values below cutoff measure).