MicroRNAs in Nonalcoholic Fatty Liver Disease: Novel Biomarkers and Prognostic Tools during the Transition from Steatosis to Hepatocarcinoma

Table 1

Descriptive summary of dysregulated miRNAs in NAFLD.

Disease	Modulation
	Upregulated	Downregulated	References
Steatosis/NASH	Pri-miR-26a-1 (in NASH), miR-122, miR-370, miR-34a, miR-16, miR-33a/b, miR-200a/b, miR-429, miR-221, miR-155, miR-181a, miR-10b, let-7b (in NASH), miR-199a (in NASH)	miR-99a/b, miR-21, miR-29c, miR-451, let-7d (in NASH), miR-199a (in steatosis), miR-128-2	[31, 35, 36, 38–40, 43, 45, 46, 52–55, 60, 65, 67, 68, 71, 76, 77, 98, 102, 109]
Fibrosis	miR-122, miR-34a, miR-199a/a*, miR-200a/b, miR-21, miR-221/222, miR-155, let-7e	miR-16, miR-15b, miR-99b, miR-197, miR-29	[31, 39, 45, 55, 66, 72, 82, 86, 87]
Cirrhosis	miR-34a, miR-21, miR-31, miR-122, miR-221, miR-155, miR-181b	miR-29	[30, 31, 85, 86, 91–93]
HCC	miR-122 (serum), miR-16, miR-33, miR-21, miR-31, miR-221/222, miR-155, miR-181a/b, let-7a/b, miR-10b	miR-122 (tissue), miR-34a, miR-200a/b, miR-99a, let-7c/g, miR-199a/b-3p	[29, 33, 40, 47, 48, 50, 51, 56, 57, 62, 65, 70, 73–75, 78, 81, 83–85, 88–92, 94–97, 99, 103, 105, 106]

NASH: nonalcoholic steatohepatits; HCC: hepatocellular carcinoma.