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BioMed Research International
Volume 2014, Article ID 746509, 8 pages
Research Article

Human Antibody Response to Aedes albopictus Salivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission

1Institut de Recherche pour le Développement (IRD), Maladie Infectieuse et Vecteurs, Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UM1-CNRS 5290-IRD, Centre IRD de Montpellier, 34394 Montpellier, France
2URMITE 198 Campus IRD-UCAD, Route des Pères Maristes, BP 1386, 18524 Dakar, Senegal
3Agence Régionale de Santé, Océan Indien, CS 61002, 97743 Saint Denis Cedex 9, La Réunion, France
4Agence Régionale de Santé, Océan Indien, CS 60050, 97408 Saint Denis Cedex 9, La Réunion, France

Received 15 August 2013; Revised 6 March 2014; Accepted 19 March 2014; Published 13 April 2014

Academic Editor: Benoît Stijlemans

Copyright © 2014 Souleymane Doucoure et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aedes borne viruses represent public health problems in southern countries and threat to emerge in the developed world. Their control is currently based on vector population control. Much effort is being devoted to develop new tools to control such arbovirus. Recent findings suggest that the evaluation of human antibody (Ab) response to arthropod salivary proteins is relevant to measuring the level of human exposure to mosquito bites. Using an immunoepidemiological approach, the present study aimed to assess the usefulness of the salivary biomarker for measuring the efficacy of Ae. albopictus control strategies in La Reunion urban area. The antisaliva Ab response of adult humans exposed to Ae. albopictus was evaluatedbefore and after vector control measures. Our results showed a significant correlation between antisaliva Ab response and the level of exposure to vectors bites. The decrease of Ae. albopictus density has been detected by this biomarker two weeks after the implementation of control measures, suggesting its potential usefulness for evaluating control strategies in a short time period. The identification of species specific salivary proteins/peptides should improve the use of this biomarker.