Genetic Networks Lead and Follow Tumor Development: MicroRNA Regulation of Cell Cycle and Apoptosis in the p53 Pathways

<table>Direct p53 regulation by miRNAs. miRNAs directly interact with<i> TP53</i> mRNA by binding to sites in the 3′-UTR. This interaction inhibits the translation of mRNA, resulting in the repression of p53 activity. ORF: open reading frame.</table>

BioMed Research International

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Figure 3

Figure 3: Genetic Networks Lead and Follow Tumor Development: MicroRNA Regulation of Cell Cycle and Apoptosis in the p53 Pathways 