The Interplay between Inflammation and Fibrosis in Kidney Transplantation

Figure 1

Renal transplant-induced fibrosis involves a complex multifactorial inflammatory process with the participation and interaction of infiltrated cells with different cell types in the kidney and is orchestrated by a network of cytokines/chemokines, growth factors, adhesion molecules, and signalling processes. These events include several phases in a dynamic process in which many of these events occur simultaneously, often in a mutually stimulating fashion.