Association of a miRNA-137 Polymorphism with Schizophrenia in a Southern Chinese Han Population
Table 2
Genotype and allele frequencies of miR-137 gene rs1625579 polymorphism in schizophrenic patients and controls.
Genotype (%)
Allele (%)
HWE
OR
95% CI
TT
GT + GG
T
G
Total
Patients
611
550 (90.02)
61 (9.98)
4.409
0.036*
1159 (94.84)
63 (5.16)
4.971
0.026*
0.097
0.756
1.450a
1.024–2.054
Control
628
541 (86.15)
87 (13.85)
1164 (92.68)
92 (7.32)
0.919
0.338
1.454b
1.045–2.024
Male
Patients
397
353 (88.92)
44 (11.08)
2.275
0.131
748 (94.21)
46 (5.79)
2.562
0.109
0.377
0.539
1.375a
0.908–2.081
Control
417
356 (85.37)
61 (14.63)
769 (92.21)
65 (7.79)
0.999
0.317
1.374b
0.930–2.032
Female
Patients
214
197 (92.06)
17 (7.94)
2.240
0.135
411 (96.03)
17 (3.97)
2.548
0.110
0.366
0.545
1.629a
0.856–3.099
Control
211
185 (87.68)
26 (12.32)
395 (93.60)
27 (6.40)
0.025
0.876
1.653b
0.887–3.079
Calculations were performed TT versus GT + GG; calculations were performed T versus G; < 0.05. HWE: Hardy-Weinberg equilibrium; OR: odds ratio; 95% CI: 95% confidence interval; nucleotides: G = guanine, T = thymine.
