The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment
Figure 1
The signaling pathway of chemoattractant GPCRs. Chemoattractant GPCRs activated by ligands elicit a cascade of signal transduction pathways involving G proteins, phospholipase C (PLC), phosphoinositide (PI) 3 kinases, protein kinase C (PKC), Ca2+, RAS, and MAPKs to mediate leukocyte migration and activation. Chemoattractant GPCRs also play a crucial role in tumor progression upon activation by their ligands culminating in cell chemotaxis, invasion, production of mediators promoting angiogenesis, and transactivation of EGFR.
