Review Article

The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment

Table 2

Chemoattractant GPCRs associated with stromal cell infiltration.

ā€‰GPCRsTumor types

Immune cells

Dendritic cellsCCR1Hepatocellular carcinoma [57]
CCR5Hepatocellular carcinoma [57], ovarian cancer [69]
CCR6Breast cancer [70, 71], colorectal cancer and lung cancer [72], lymphoma [73], melanoma [58, 72], lymphocyte-rich gastric cancer [74], renal cell carcinoma [62], thyroid cancer [75]
CCR7Breast cancer [76], renal cell carcinoma [62]
CXCR1/2Colorectal cancer [77ā€“79], gastric cancer [79], hepatocellular carcinoma [78], pancreatic cancer [78]

Myeloid-derived suppressor cellsCCR2 Basal cell carcinomas [80], melanoma [66]
CXCR2 Colitis-associated cancer [81]
CXCR4 Gastric cancer [82], ovarian cancer [83]

Tumor-associated macrophagesPAFR Melanoma [84]
CCR2 Breast cancer [85], cervical cancer [86], colitis-associated cancer [87], lymphoma [88], nasopharyngeal carcinoma [89], oral cancer [90], prostate cancer [91], pancreatic cancer [92], thyroid cancer [93]
CCR4 Lung cancer [94]
CCR5 Hepatocellular carcinoma [95], nasopharyngeal carcinoma [89]
CXCR3Breast cancer [42]
CX3CR1 Breast cancer [96], glioma [97]

Regulatory T cellsCCR4 Breast cancer [98], cervical cancer [99], Hodgkin lymphoma [100], gastric cancer [101], glioma [102], melanoma [103]
CCR5 Colorectal cancer [104], lymphoma [105], pancreatic cancer [106], renal cell carcinoma [107]
CCR6 Breast cancer [108], colorectal cancer [109], hepatocellular carcinoma [110], Hodgkin lymphoma [111], renal cell carcinoma [107]
CCR7 Melanoma [112], ovarian cancer [113]
CCR10 Ovarian cancer [35]
CXCR1 Lung cancer, mesothelioma, melanoma [114]
CXCR3 Renal cell carcinoma [107]
CXCR4 Breast cancer [115], B cell lymphoma [116], hepatocellular carcinoma [117], lung cancer [118], glioma [119], ovarian cancer [120, 121]
CXCR6 Nasopharyngeal carcinoma [122], renal cell carcinoma [107]

Stromal cells

Mesenchymal stem cellsFPR2Ovarian tumor [123]
CCR2Breast cancer [124], glioma [125], lymphoma [88]
CXCR1Glioma [126, 127]
CXCR2Kidney cancer [128], glioma [127]
CXCR4Breast cancer [129], gastric cancer [130], glioma [125, 131, 132]
CXCR6 Glioma [132], prostate cancer [133]
CX3CR1Colorectal cancer [134]