Alterations of the Myovesical Plexus of the Human Overactive Detrusor
N-Cadherin positive strings and interfascicular cells. N-Cadherin (green) double labeled with PGP9.5 (red) and counterstained with Dapi (blue). Detrusor smooth muscle fascicles (Det) are demarcated by the dotted orange line. Note green background signal in smooth muscle cells that was upgraded to facilitate tissue orientation. N-Cadherin+ string closely associated to an adjacent detrusor smooth muscle fascicle. A cell expressing N-cadherin is housed within the interfascicular connective tissue plane (arrowhead). Note the close association of a PGP9.5+ nerve profile (#) with N-cadherin+ cells. PGP9.5 is not intrafascicularly expressed. Magnification X400. Binocular epifluorescent microscopy.