The Low Chamber Pancreatic Cancer Cells Had Stem-Like Characteristics in Modified Transwell System: Is It a Novel Method to Identify and Enrich Cancer Stem-Like Cells?
High resistance to gemcitabine in lower chamber cells. Under the condition without gemcitabine, the cell viability of the bulk pancreatic cells was higher than those of the lower chamber cells and the upper chamber cells. The proliferation ability of the three groups’ cells was inhibited by gemcitabine. However, the survival rate of lower chamber cells was significantly higher than those of the bulk pancreatic cells and the upper chamber cells. Significant differences in chemosensitivity were observed among the lower chamber cells, the bulk pancreatic cells, and the upper chamber cells (*, **, and ***).
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