The Low Chamber Pancreatic Cancer Cells Had Stem-Like Characteristics in Modified Transwell System: Is It a Novel Method to Identify and Enrich Cancer Stem-Like Cells?
Comparison of newly generated tumors between the lower chamber cells and parental Panc-1 cells in BALB/c nude mice. (a) 1×104 of the lower chamber cells and the bulk Panc-1 cells were injected into BALB/c nude mice on the right and left flanks, respectively. The lower chamber cells formed tumors 2 weeks later, while Panc-1 cells failed. (b) of the lower chamber cells and the bulk Panc-1 cells were injected into BALB/c nude mice on the right and left flanks, respectively. Both of the two groups formed tumors 2 weeks later. (c) Gross appearance of a representative tumor formed by the same number () of bulk Panc-1 cells and the lower chamber cells into BALB/c nude mice. (d) Growth curves showed that the growth speed of the lower chamber cells group was much faster than their parallel Panc-1 cells. L represents the lower chamber cells; C represents the bulk pancreatic cells (*, **, and ***).
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