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BioMed Research International
Volume 2014 (2014), Article ID 764268, 9 pages
Research Article

Alterations in Red Blood Cell Deformability during Storage: A Microfluidic Approach

1Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
2Department of Physical Organic Chemistry, Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
3Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Reinier Postlaan 4, 6525 CG Nijmegen, The Netherlands

Received 5 June 2014; Accepted 15 August 2014; Published 10 September 2014

Academic Editor: Ulrich Salzer

Copyright © 2014 Judith C. A. Cluitmans et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental Video 1: Deformation and relaxation of RBCs passing through microfluidic channels mimicking microcirculation in vivo. RBCs transit through the microchannels with an axisymmetric bullet-like shape. They relax back to their initial disc-like shape as soon as they exit into the relaxation zone.

  1. Supplementary Materials