Cardiac Phosphoproteomics during Remote Ischemic Preconditioning: A Role for the Sarcomeric Z-Disk Proteins
Table 2
RIPC-induced changes in phosphoproteins measured using TMT. Data shown are for the second group of hearts (Series 2; 3 control and 3 RIPC). Fold change was calculated by taking average values for control and for RIPC.
Phosphoproteins
Protein accession
Fold change
value
value normalised to p-GAPDH
Myozenin-2
Q9JJW5
1.9
0.015*
0.020*
Tropomyosin alpha-1 chain
P09493
1.5
0.036*
0.08
Troponin I
P48787
1.6
0.029*
0.043*
M-protein
O55124
1.4
0.023*
0.016*
Eif4g1 protein
Q8R2V4
1.3
0.010*
0.040*
Isoform 2 of titin
A2ASS6-2
1.6
0.061
0.12
Junctophilin-2
Q9BR39
1.7
0.070
0.053
Isoform A3B of troponin T, cardiac muscle
P50752-2
1.2
0.06
0.064
Ataxin-2
F6V8M6
0.8
0.005*
0.043*
Isoform Tau-C of microtubule-associated protein tau
P10637-4
0.8
0.008*
0.050
Centrosomal protein of 170 kDa
H7BX26
0.8
0.031*
0.072
Protein kinase, cAMP dependent regulatory, type I, alpha
A2AI69
0.7
0.019*
0.031*
THUMP domain-containing protein 1
Q99J36
0.8
0.028*
0.09
CDKN2A-interacting protein
Q9NXV6
0.8
0.060
0.103
-value calculated using unpaired -test ( considered as significant). values between 0.05–0.1 indicate strong trend.
