Distinct Characteristics of Mandibular Bone Collagen Relative to Long Bone Collagen: Relevance to Clinical Dentistry
Figure 1
The collagen cross-linking pathway in mineralized tissues. The collagen cross-linking pathway in soft tissues arises from the both at the C- and N-telopeptide domains (-pathway). In mineralized tissue, it does so from the mostly at the C-telopeptide domain (-pathway). In mineralized tissues, the Lys residue at the C-telopeptide domain is converted into Hyl through the action of LH2b, followed by the conversion of the Hyl into the through the action of LOX. To make the major crosslinks, the immature crosslink, deH-DHLNL, is first formed by pairing of the with the Hyl at the helical domain of the neighboring molecule ( × Hyl), and the mature crosslink, Pyr, is then formed by a spontaneous condensation reaction ( × × Hyl). To make the minor crosslinks, the immature crosslink, deH-HLNL, is formed ( × Lys), and then the mature crosslink, d-Pyr, is formed ( × × Lys). The value of Pyr/deH-DHLNL presents collagen maturation rate. : the aldehyde form of Lys; : the aldehyde form of Hyl; TELO: the telopeptide domain; HEL: the helical domain.
