Gender-Dependent Effect of GSTM1 Genotype on Childhood Asthma Associated with Prenatal Tobacco Smoke Exposure

Table 2

Multivariate regression analysis of childhood asthma in children with the GSTM1 null or positive genotype.

	GSTM1 null			GSTM1 positive
		OR	95% CI		OR	95% CI
Male gender	0.003	2.317	1.342–4.000	0.126	1.606	0.875–2.950
Preterm (<37 weeks)	0.583	0.725	0.230–2.285	0.723	0.784	0.205–2.999
Maternal atopy^†	0.488	1.235	0.681–2.240	0.595	1.206	0.604–2.409
Paternal atopy^†	0.228	1.419	0.803–2.509	0.125	1.643	0.871–3.101
Prenatal TSE	0.003	2.308	1.333–3.997	0.553	1.223	0.629–2.377

Atopy is defined by phenotypic asthma, allergic rhinitis, or atopic dermatitis along with a detectable serum specific IgE (≥0.35 kU/L) response to one or more common allergens (egg white, cow’s milk, peanut, shrimp, house dust mite, or German cockroach).