Glucagon Effects on ³H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis

Table 1

Calculated values of 𝑈_net,  𝑈_max, and backflux (BF) before and during anaphylaxis in the absence and in the presence of glucagon as well as percentage of inhibition (% INH) of ³H-histamine uptake parameters during anaphylaxis.

	𝑈net (%)		𝑈max (%)		BF (%)
	Without glucagon	With glucagon	Without glucagon	With glucagon	Without glucagon	With glucagon
Before anaphylaxis	12.4±1.23^∗†	17.34±2.1^∗	29.29±1.37^†	27.18±1.41	57.6±4.46^∗	36.38±4.94^∗
During anaphylaxis	7.00±1.24^∗†	16.15±1.66^∗	15.05±1.69^∗†	24.15±1.49^∗	53.72±4.0^∗	33.24±3.63^∗
% INH	43.89±5.26		48.51±6.29

Data are presented as mean ± SD, 𝑛=8.
*Significantly different values (𝑃<0.05) between the period with and without glucagon.
^†Significantly different values (𝑃<0.05) between the period before and during anaphylaxis.