Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis
Figure 2
The genome-wide distribution of CpG dinucleotides. (a) Repeats contribute over 50% of CpG dinucleotides in the human genome. The distributions of CpG dinucleotides were calculated based on the hg19 reference genome sequences downloaded from the UCSC database. (b) The average CpG number in an Alu element varies between Alu subfamilies. The -axis lists the Alu subfamilies, among which AluYa-k includes AluYa, AluYb, AluYc, AluYd, AluYf, AluYg, and AluYk subfamilies. The -axis shows the average number of CpG dinucleotides in a full-length Alu element. Only Alu elements with a sequence length equal to or greater than 250 bp were included in analysis.
