Citrate Anticoagulation for CRRT in Children: Comparison with Heparin

Table 3

Characteristics of CRRT in children treated with heparin and citrate.

	Citrate	Heparin	𝑃
	Median (IQR)	Median (IQR)
Blood flow (mL/min)/weight (kg)	3.2 (2–3.8)	5.0 (3.8–5.6)	0.008
Citrate dose (mmol/L)	2.6 (2.3–2.9)	—	—
Citrate flow (citrate 12 mmol/L); (mL/kg/h)	67 (50.9–73.7)	—	—
Citrate flow (citrate 18 mmol/L); (mL/kg/h)	28 (21.3–30.8)	—	—
Final citrate dose (mmol/L)	2.9 (2.5–3.2)	—	—
Heparin (UI/kg/h)	—	15 (12–25)	—
Extraction rate (mL/h)	75 (50–97.5)	60 (50–90)	0.526
Dialysis (mL/h)	325 (50–600)	400 (200–750)	0.289
Postfilter substitution (mL/h)	50 (0–50)	300 (140–500)	0.026
Total CRRT doses (mL/kg/h)	69 (52–85)	59 (44–70)	0.154
CRRT duration (h)	155 (92–204)	166 (92–271)	0.736

IQR: interquartile range.