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BioMed Research International
Volume 2014, Article ID 787143, 11 pages
http://dx.doi.org/10.1155/2014/787143
Review Article

BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management

1Dipartimento di Scienze Mediche e Chirurgiche, Unità di Genetica Medica, Università di Bologna, Policlinico S. Orsola-Malpighi, Via Massarenti 9 [Pad. 11, 2° Piano], 40138 Bologna, Italy
2SSD Oncologia Ginecologica, AOU di Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy
3UO Anatomia Patologica, AOU di Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy
4SSD Oncologia Medica, AOU di Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy
5Dipartimento Di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, 73100 Lecce, Italy
6UO Genetica Medica, AOU di Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy

Received 21 January 2014; Revised 8 July 2014; Accepted 10 July 2014; Published 22 July 2014

Academic Editor: YongSang Song

Copyright © 2014 Giulia Girolimetti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ovarian cancer (OC) mostly arises sporadically, but a fraction of cases are associated with mutations in BRCA1 and BRCA2 genes. The presence of a BRCA mutation in OC patients has been suggested as a prognostic and predictive factor. In addition, the identification of asymptomatic carriers of such mutations offers an unprecedented opportunity for OC prevention. This review is aimed at exploring the current knowledge on epidemiological and molecular aspects of BRCA-associated OC predisposition, on pathology and clinical behavior of OC occurring in BRCA mutation carriers, and on the available options for managing asymptomatic carriers.