Review Article

BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management

Table 1

Distribution of morphology and grade of ovarian tumors arising in BRCA1 and BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) [60].

FactorBRCA1 
(%)
BRCA2 
(%)
Total 
(%)

MorphologySerous534 (66)191 (70)725 (67)
Mucinous11 (1)4 (1)15 (1)
Endometrioid94 (12)33 (12)127 (12)
Clear cell8 (1)8 (3)16 (1)
Other166 (20)36 (13)202 (19)
Total8132721,085

Grade117 (3)11 (6)28 (4)
2104 (20)37 (21)141 (20)
3407 (77)128 (73)535 (76)
Total528176704