18FDG, [18F]FLT, [18F]FAZA, and 11C-Methionine Are Suitable Tracers for the Diagnosis and In Vivo Follow-Up of the Efficacy of Chemotherapy by miniPET in Both Multidrug Resistant and Sensitive Human Gynecologic Tumor Xenografts
Figure 3
Effect of combined treatment on the 18FDG and 18F-FLT uptake of Pgp positive and negative human ovarian (left side) and epidermoid carcinoma (right side) tumors. (a) 18FDG and 18F-FLT miniPET images of control and combined treated Pgp− (left side, black arrows) and Pgp+ (right side, red arrows) tumor-bearing mice (coronal sections). No tumors can be visualized in the treated animals. (b) The SUVmean and SUVmax and the mean and maximum T/M ratios are displayed (bars represent mean ± SEM). Statistically significant differences in comparison to combined treated tumors are indicated (, , and ).
