Review Article
Multifunctional Role of ATM/Tel1 Kinase in Genome Stability: From the DNA Damage Response to Telomere Maintenance
Table 1
Components of the Saccharomyces cerevisiae DNA damage response pathway and their orthologs in Homo sapiens.
| | H. sapiens | S. cerevisiae | Description |
| | ATM | Tel1 | Protein kinase- (PIKK-) DNA damage response and telomere length regulation | | ATR | Mec1 | Protein kinase- (PIKK-) DNA damage response and telomere length regulation | | MRE11-RAD50-NBS1 | Mre11-Rad50-Xrs2 | DSB sensing, nuclease | | CHK2 | Rad53 | DNA damage response protein kinase; checkpoint effector | | CHK1 | Chk1 | Protein kinase; checkpoint effector; mediates cell-cycle arrest | | CtIP | Sae2 | Endonuclease | | EXO1 | Exo1 | 5′-3′ Exonuclease | | BLM | Sgs1 | DNA helicase | | DNA2 | Dna2 | ATP-dependent nuclease and helicase | | RAD9-RAD1-HUS1 | Ddc1-Rad17-Mec3 | Checkpoint clamp (9-1-1 complex) | | 53BP1; BRCA1; MDC1 | Rad9 | DNA damage-dependent checkpoint protein |
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