Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 791238, 9 pages
http://dx.doi.org/10.1155/2014/791238
Review Article

Alzheimer’s Disease and HLA-A2: Linking Neurodegenerative to Immune Processes through an In Silico Approach

Area of Basic Sciences, Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia

Received 22 January 2014; Accepted 8 July 2014; Published 17 August 2014

Academic Editor: Francesco Pappalardo

Copyright © 2014 Ricardo A. Cifuentes and Juan Murillo-Rojas. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Alves, S. Veiga, T. Souza, M. B. Toralles, and A. L. Da Silva-Bacellar, “The role of the human histocompatibility antigens in the pathogenesis of neurological disorders,” Revista de Neurologia, vol. 44, no. 5, pp. 298–302, 2007. View at Google Scholar · View at Scopus
  2. P. H. St George-Hyslop and A. Petit, “Molecular biology and genetics of Alzheimer's disease,” Comptes Rendus Biologies, vol. 328, no. 2, pp. 119–130, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. L. A. Panossian, V. R. Porter, H. F. Valenzuela et al., “Telomere shortening in T cells correlates with Alzheimer's disease status,” Neurobiology of Aging, vol. 24, no. 1, pp. 77–84, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Schindowski, A. Eckert, J. Peters et al., “Increased T-cell reactivity and elevated levels of CD8+ memory T-cells in Alzheimer's disease-patients and T-cell hyporeactivity in an Alzheimer's disease-mouse model: Implications for immunotherapy,” NeuroMolecular Medicine, vol. 9, no. 4, pp. 340–354, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Larbi, G. Pawelec, J. M. Witkowski et al., “Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 17, no. 1, pp. 91–103, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Bonotis, E. Krikki, V. Holeva, C. Aggouridaki, V. Costa, and S. Baloyannis, “Systemic immune aberrations in Alzheimer's disease patients,” Journal of Neuroimmunology, vol. 193, no. 1-2, pp. 183–187, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Candore, C. R. Balistreri, G. Colonna-Romano, D. Lio, and C. Caruso, “Major histocompatibility complex and sporadic Alzheimer's disease: a critical reappraisal,” Experimental Gerontology, vol. 39, no. 4, pp. 645–652, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Neill, M. D. Curran, D. Middleton et al., “Risk for Alzheimer's disease in older late-onset cases is associated with HLA-DRB1*03,” Neuroscience Letters, vol. 275, no. 2, pp. 137–140, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. F. R. Guerini, C. Tinelli, E. Calabrese et al., “HLA-A*01 is associated with late onset of Alzheimer's disease in Italian patients,” International Journal of Immunopathology and Pharmacology, vol. 22, no. 4, pp. 991–999, 2009. View at Google Scholar · View at Scopus
  10. D. Culpan, S. H. MacGowan, J. M. Ford et al., “Tumour necrosis factor-α gene polymorphisms and Alzheimer's disease,” Neuroscience Letters, vol. 350, no. 1, pp. 61–65, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. D. J. Lehmann, H. Wiebusch, S. E. Marshall et al., “HLA class I, II & III genes in confirmed late-onset Alzheimer's disease,” Neurobiology of Aging, vol. 22, no. 1, pp. 71–77, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. J. M. Harris, A. M. Cumming, N. Craddock, D. St Clair, and C. L. Lendon, “Human leucocyte antigen-A2 increases risk of Alzheimer's disease but does not affect age of onset in a Scottish population,” Neuroscience Letters, vol. 294, no. 1, pp. 37–40, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. S. L. Ma, N. L. S. Tang, C. W. C. Tam et al., “Association between HLA-A alleles and Alzheimer's disease in a Southern Chinese community,” Dementia and Geriatric Cognitive Disorders, vol. 26, no. 5, pp. 391–397, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Zareparsi, D. M. James, J. A. Kaye, T. D. Bird, G. D. Schellenberg, and H. Payami, “HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease,” Neurology, vol. 58, no. 6, pp. 973–975, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. R. A. Cifuentes, A. Rojas-Villarraga, and J.-M. Anaya, “Human leukocyte antigen class II and type 1 diabetes in Latin America: a combined meta-analysis of association and family-based studies,” Human Immunology, vol. 72, no. 7, pp. 581–586, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. K. K. Nicodemus, “Catmap: case-control and TDT meta-analysis package,” BMC Bioinformatics, vol. 9, article 130, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Jelier, M. J. Schuemie, A. Veldhoven, L. C. J. Dorssers, G. Jenster, and J. A. Kors, “Anni 2.0: a multipurpose text-mining tool for the life sciences,” Genome Biology, vol. 9, no. 6, article R96, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Jelier, G. Jenster, L. C. J. Dorssers et al., “Text-derived concept profiles support assessment of DNA microarray data for acute myeloid leukemia and for androgen receptor stimulation,” BMC Bioinformatics, vol. 8, article 14, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. R. A. Cifuentes, D. Restrepo-Montoya, and J. Anaya, “The autoimmune tautology: an in silico approach,” Autoimmune Diseases, vol. 2012, Article ID 792106, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. S. I. Berger, J. M. Posner, and A. Ma'ayan, “Genes2Networks: connecting lists of gene symbols using mammalian protein interactions databases,” BMC Bioinformatics, vol. 8, article 372, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. P. J. Henschke, D. A. Bell, and R. D. T. Cape, “Alzheimer's disease and HLA,” Tissue Antigens, vol. 12, no. 2, pp. 132–135, 1978. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Sulkava, S. Koskimies, J. Wikstrom, and J. Palo, “HLA antigens in Alzheimers disease,” Tissue Antigens, vol. 16, no. 2, pp. 191–194, 1980. View at Google Scholar · View at Scopus
  23. C. B. Wilcox, E. A. Caspary, and P. O. Behan, “Histocompatibility antigens in Alzheimer's disease. A preliminary study,” European Neurology, vol. 19, no. 4, pp. 262–265, 1980. View at Publisher · View at Google Scholar · View at Scopus
  24. L. J. Whalley, S. J. Urbaniak, C. Darg, J. F. Peutherer, and J. E. Christie, “Histocompatibility antigens and antibodies to viral and other antigens in Alzheimer pre-senile dementia,” Acta Psychiatrica Scandinavica, vol. 61, no. 1, pp. 1–7, 1980. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Majsky and M. Vojtechovsky, “Non-relationship between the HLA system and the senile form of Alzheimer's disease,” Archiv fur Psychiatrie und Nervenkrankheiten, vol. 233, no. 5, pp. 381–383, 1983. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Reed, D. Thompson, R. Mayeaux, and N. Suciu Foca, “HLA antigens in Alzheimer's disease,” Tissue Antigens, vol. 21, no. 2, pp. 164–167, 1983. View at Google Scholar · View at Scopus
  27. E. Reisner, A. Heyman, T. Weinberg, D. Dawson, and E. Ciftan, “Lack of association between Alzheimer's disease and histocompatibility antigens,” Tissue Antigens, vol. 21, no. 1, pp. 31–34, 1983. View at Google Scholar · View at Scopus
  28. E. B. Renvoize, “An HLA and family study of Alzheimer's disease,” Psychological Medicine, vol. 14, no. 3, pp. 515–520, 1984. View at Publisher · View at Google Scholar · View at Scopus
  29. G. W. Small and S. S. Matsuyama, “HLA-A2 as a possible marker for early-onset Alzheimer disease in men,” Neurobiology of Aging, vol. 7, no. 3, pp. 211–214, 1986. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Payami, J. Kaye, W. Becker, D. Norman, and P. Wetzsteon, “HLA-A2, or a closely linked gene, confers susceptibility to early-onset sporadic Alzheimer's disease in men,” Neurology, vol. 41, no. 10, pp. 1544–1548, 1991. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Middleton, H. Mawhinney, M. D. Curran et al., “Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease,” Neuroscience Letters, vol. 262, no. 2, pp. 140–142, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. G. W. Small, W. K. Scott, S. Komo et al., “No association between the HLA-A2 allele and Alzheimer disease,” Neurogenetics, vol. 2, no. 3, pp. 177–182, 1999. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Araria-Goumidi, J. C. Lambert, D. Cottel, P. Amouyel, and M. C. Chartier-Harlin, “No association of the HLA-A2 allele with Alzheimer's disease,” Neuroscience Letters, vol. 335, no. 2, pp. 75–78, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Listì, G. Candore, C. R. Balistreri et al., “Association between the HLA-A2 allele and Alzheimer disease,” Rejuvenation Research, vol. 9, no. 1, pp. 99–101, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. F. R. Guerini, E. Calabrese, C. Agliardi et al., “Association study of the HLA-A2 allele in Italian Alzheimer disease patients,” Neurobiology of Aging, vol. 30, no. 12, pp. 2082–2083, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Endo, T. Yamamoto, and F. Kuzuya, “HLA system in senile dementia of Alzheimer type and multi-infarct dementia in Japan,” Archives of Gerontology and Geriatrics, vol. 5, no. 1, pp. 51–56, 1986. View at Publisher · View at Google Scholar · View at Scopus
  37. M. A. Fernandez-Viña, M. Falco, Y. Sun, and P. Stastny, “DNA typing for HLA class I alleles: I. Subsets of HLA-A2 and of -A28,” Human Immunology, vol. 33, no. 3, pp. 163–173, 1992. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Tuli, M. Sharma, X. Wang et al., “Amyloid precursor-like protein 2 association with HLA class i molecules,” Cancer Immunology, Immunotherapy, vol. 58, no. 9, pp. 1419–1431, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. A. P. Correia, J. P. Pinto, V. Dias, C. Mascarenhas, S. Almeida, and G. Porto, “CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation,” Neuroscience Letters, vol. 457, no. 3, pp. 129–132, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. J. Vieira, C. S. Cardoso, J. Pinto et al., “A putative gene located at the MHC class I region around the D6S105 marker contributes to the setting of CD8+ T-lymphocyte numbers in humans,” International Journal of Immunogenetics, vol. 34, no. 5, pp. 359–367, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. I. K. Jang, J. Zhang, and H. Gu, “Grb2, a simple adapter with complex roles in lymphocyte development, function, and signaling,” Immunological Reviews, vol. 232, no. 1, pp. 150–159, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. D. J. Lehmann, M. C. N. M. Barnardo, S. Fuggle et al., “Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?” Journal of Neuroinflammation, vol. 3, article 33, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. M. M. Corsi, F. Licastro, E. Porcellini et al., “Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration,” Biogerontology, vol. 12, no. 5, pp. 451–454, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. A. MacIntyre, R. Abramov, C. J. Hammond et al., “Chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells,” Journal of Neuroscience Research, vol. 71, no. 5, pp. 740–750, 2003. View at Publisher · View at Google Scholar · View at Scopus
  45. V. Zota, A. Nemirovsky, R. Baron et al., “HLA-DR alleles in amyloid β-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele,” Journal of Immunology, vol. 183, no. 5, pp. 3522–3530, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. B. W. Carey, D. Y. Kim, and D. M. Kovacs, “Presenilin/γ-secretase and α-secretase-like peptidases cleave human MHC Class I proteins,” Biochemical Journal, vol. 401, no. 1, pp. 121–127, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. L. Bertram and R. E. Tanzi, “Genome-wide association studies in Alzheimer's disease,” Human Molecular Genetics, vol. 18, no. 2, pp. R137–R145, 2009. View at Publisher · View at Google Scholar · View at Scopus