Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population

Table 4

Haplotype frequency distribution (case versus control) of the three polymorphisms of the endothelial nitric oxide synthase (eNOS) gene in the study population.

Variants	Haplotype	Haplotype frequency		OR (95% CI)	value
		Case; ()	Control; ()
eNOS 4 and eNOS 7	bG	0.5550	0.7912	0.33; (0.23–0.46)	0.000*
	aT	0.0650	0.0112	6.08; (1.97–20.99)	0.002*
	aG	0.1850	0.1288	1.55; (1.00–2.39)	0.048*
	bT	0.1950	0.0688	3.28; (1.95–5.52)	0.000*
eNOS 4 and eNOS T786C	bT	0.5775	0.6794	0.64; (0.47–0.89)	0.006*
	bC	0.1725	0.1806	0.94; (0.63–1.42)	0.843
	aT	0.1925	0.1106	1.89; (1.21–2.96)	0.004*
	aC	0.0575	0.0294	2.17; (0.96–5.02)	0.07
eNOS 7 and eNOS T786C	GT	0.5698	0.7268	0.50; (0.36–0.69)	0.000*
	GC	0.1702	0.1932	0.86; (0.57–1.28)	0.47
	TT	0.2002	0.0632	3.73; (2.19–6.38)	0.000*
	TC	0.0598	0.0168	3.66; (1.38–10.26)	0.006*

OR: odds ratio.
CI: confidence interval.
*Statistically significant ( value ≤ 0.05).