In Search of the Active Metabolites of an Anticancer Piperazinedione, TW01003, in Rats

Table 1

Summary of pharmacokinetic parameters of TW01003 and TW01003 sulfate after i.v. administration of TW01003 (𝑛=6).

PK parameters	TW01003	TW01003 sulfate
	Mean ± SD	Mean ± SD
C max (μg/mL)	2.20 ± 0.25	1.31 ± 0.64
t 1/2 (h)	0.76 ± 0.14	1.31 ± 0.22
AUCall (h∗μg/mL)	0.28 ± 0.04	0.52 ± 0.20
AUCINF (h∗μg/mL)	0.29 ± 0.04	0.71 ± 0.25
CL (L/h/kg)	7.05 ± 1.12	3.08 ± 0.90
AUMCINF (h∗h∗μg/mL)	0.06 ± 0.02	1.01 ± 0.36
MRTINF (h)	0.20 ± 0.06	1.44 ± 0.33
𝑉𝐷 (L/kg)	1.41 ± 0.41	4.43 ± 1.52

C _max: peak concentration; t _1/2: half-life; AUC_all: area under curve from time 0 to the last sampling time; AUC_INF: area under curve from time 0 to infinite; CL: clearance; AUMC_INF: area under the moment-time curve from time 0 to infinite; MRT_INF: mean residence time from time 0 to infinite; 𝑉_𝐷: volume of distribution.