Novel Lipid-Free Nanoformulation for Improving Oral Bioavailability of Coenzyme Q10

Table 2

Pharmacokinetics parameters of CoQ10 in rats after a single oral administration of CoQ10 suspension and nano-CoQ10 formulations modified with various surfactants.

	𝑡1/2 (h)	𝑇max (h)	𝐶max (𝜇g/mL)	AUC0--48h (𝜇g/mL × h)
Nano-CoQ10-TPGS	17.37 ± 2.56	6 ± 0	1.49±0.05^⋆#	30.38±0.59^⋆#§
Nano-CoQ10-PHCO	20.25 ± 1.23	7 ± 0	1.69±0.05^⋆	41.02±0.47^⋆
Nano-CoQ10-PSAE	21.01 ± 2.04	6 ± 0	1.74±0.1^⋆	39.81±2.51^⋆
Nano-CoQ10-SP	20.52 ± 2.78	6 ± 0	1.55±0.15^⋆	34.35±2.58^⋆#
Nano-CoQ10-SL	18.52 ± 1.42	6 ± 0	1.35±0.05^⋆#§	26.7±1.13^⋆#§
CoQ10-Suspension	18.27 ± 3.71	6.33 ± 0.58	0.58 ± 0.02	11.47 ± 0.77

(𝑛=6, mean ± SD).
^⋆𝑃<0.01 versus CoQ10-Suspension.
^#𝑃<0.05 versus nano-CoQ10-PHCO.
^§𝑃<0.05 versus Nano-CoQ10-SP.