Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System

Figure 3

Dexamethasone release profiles of the 2 representative rabbits (rabbits ID 22-6 and ID 23-12). There was no lag period immediately after dexamethasone administration. During the first day after the drug cartridge insertion, a considerable amount of the drug was released and the maximum concentration was detected at between 4 hours and 12 hours after administration. From the second day, a sustained release was maintained and the concentration provided relatively constant levels of dexamethasone for more than 7 weeks.