In Vitro Chronic Administration of ERbeta Selective Ligands and Prostate Cancer Cell Growth: Hypotheses on the Selective Role of 3beta-Adiol in AR-Positive RV1 Cells

Figure 7

Transcriptional activity of ERbeta agonists in Rv1 (a) and in HEK 293 (b) cells: data are expressed as mean ± SD of the ratio between the luminescence (RLU) of the experimental over the control reporter;^∗𝑃<0.05 versus C and 3beta-Adiol 1 and 10 nM;^∗∗∗𝑃<0.001 versus C and 3beta-Adiol 1 and 10 nM; ^§§§𝑃<0.001 versus C and 8beta-VE2 1 and 10 nM; ^∧∧∧𝑃<0.001 versus 8beta-VE2 1 nM.

(a) Rv1 (endogenous ERbeta)

(b) HEK293 (transfected ERbeta1)