Evidence for the Use of Isoflurane as a Replacement for Chloral Hydrate Anesthesia in Experimental Stroke: An Ethical Issue

Table 1

Characteristics of anesthesia using chloral hydrate or isoflurane.

Agent	Administration route	Dose	Anesthesia duration	Mechanism of action
Chloral hydrate (CHLO)	Intraperitoneal	300 mg/kg	90 min	GABA A stimulation
Isoflurane (ISO)	Gas mask	Induction: 4%; Maintenance: 2%; Output: 2 L/min	20 min	Two-pore-domain potassium channels activation