Review Article
Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies
Table 2
Selected miRNAs targeting oncogenes.
| Natural agent | miRNA | Regulation | Target(s) and function(s) | Cancer type | Reference |
|
Curcumin | miR-181b | Up | Targets CXCL1 and CXCL2; inhibited migration through MMP | Breast | [41] | miR-15a, miR-16 | Up | miRNA inhibition upregulates Bcl-2 and WT1 and induces cell growth | Breast; leukemia | [42, 43] | miR-203 | Up | Targets Akt2 and Src; inhibits cell proliferation, invasion, and migration; and induces cell cycle arrest and apoptosis | Bladder | [44] | miR-22 | Up | Targets Erbb3; inhibits cell proliferation and migration | Pancreatic | [45] |
| Resveratrol | miR-663, miR-744 | Up | Targets eEF1A; inhibits cell proliferation | Breast | [51] | miR-21 | Down | Upregulates Bcl-2; increases apoptosis | Pancreatic | [52] | miR-622 | Up | Targets K-Ras; inhibits proliferation and colony formation in vitro and tumorigenicity in vivo | Lung | [53] |
| Genistein | miR-34a | Up | Targets HOTAIR | Prostate | [54] | miR-574-3p | Up | Targets RAC1, EGFR, and EP300; inhibits cell proliferation, migration, and invasion; and induces apoptosis | Prostate | [55] | miR-1296 | Up | miRNA inhibition upregulates MCM2 and vice versa | Prostate | [56] |
| EGCG | miR-16 | Up | Targets Bcl-2 | Hepatocellular | [57] |
| DIM | miR-21 | Up | Targets Cdc25A | Pancreatic | [58] | let-7 family | Up | Downregulates EZH2 | Prostate | [59] | miR-146 | Up | Downregulates EGFR, IRAK-1, NF-kB, and MTA2; inhibits cell invasion | Pancreatic | [60] |
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