Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies

Table 3

Selected miRNAs targeting tumour suppressor genes.

Natural agent	miRNA	Regulation	Target(s) and function(s)	Cancer type	Reference
Curcumin	miR-186*	Down	Targets caspase-10; inhibits apoptosis	Lung	[46, 47]
	miR-21	Down	Targets PDCD4	Colon	[48]
Resveratrol	miR-663	Up	Targets TGFβ1	Colon	[61]
	miR-17-92, miR-10ab	Down	Targets PTEN	Prostate	[62]
	miR-21	Down	Targets PDCD4 and maspin	Prostate	[63, 64]
Genistein	miR-221, miR-222	Down	Targets ARH1	Prostate	[65]
	miR-151	Down	miRNA inhibition suppresses cell migration and invasion; targets N4BP1, CASZ1, IL1RAPL1, SOX17, and ARHGDIA	Prostate	[66]
	miR-23b-3p	Down	Targets PTEN; miRNA inhibition induces apoptosis and inhibits invasion	Renal	[67]
	miR-1260b	Down	Targets sFRP1, Dkk2 and, Smad4; induces cell proliferation and invasion; inhibits apoptosis	Renal; Prostate	[68, 69]
	miR-223	Down	Upregulates Fbw7; miRNA inhibition suppresses cell growth and induces apoptosis	Pancreatic	[70]
	miR-27a	Down	Upregulates ZBTB10 and Sprouty2; miRNA inhibition suppresses cell growth, migration, and invasion and induces apoptosis	Melanoma; Ovarian; Pancreatic	[71–73]
EGCG	miR-98-5p	Down	miRNA inhibition enhances cisplatin-induced apoptosis and increases p53 expression	Lung	[74]
I3C	miR-21	Down	Downregulates PTEN, PDCD4, and RECK	Lung; Pancreatic	[75, 76]
	miR-221	Down	Upregulates PTEN, p27kip1, p57kip2, and PUMA; increases cell proliferation	Pancreatic	[77]