Invasive Potential of Melanoma Cells Correlates with the Expression of MT1-MMP and Regulated by Modulating Its Association with Motility Receptors via N-Glycosylation on the Receptors
Figure 4
Effect of glycosylation on regulating association of β1 integrin and MT1-MMP. (a) Biotinylated lectin L-PHA staining of B16BL6 (−SW) and the same cells treated with swainsonine (+SW). (b) Colocalization of MT1-MMP (green) with β1 integrin (red) in B16F10, B16BL6, and B16BL6 cells treated with SW (B16BL6 SW). Colocalized or merged images were shown in yellow. Scale bar 20 μm.