Clinical Study
Multidisciplinary Management of Hepatocellular Carcinoma in Clinical Practice
Table 3
Cumulative toxicity.
| | | Patients | Cycles |
| | Number | 10 | 45 | | NCI-CTC Grade | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | | Nausea (%) | 1 (10) | — | — | — | 1 (2) | — | — | — | | Vomiting (%) | 1 (10) | — | — | — | 1 (2) | — | — | — | | Anorexia (%) | 4 (40) | 3 (30) | 1 (10) | — | 14 (31) | 4 (9) | 1 (2) | — | | Diarrhea (%) | 1 (10) | 4 (40) | — | — | 6 (13) | 7 (16) | — | — | | Hypoalbuminemia (%) | — | — | — | — | — | — | — | — | | Constipation (%) | — | 2 (20) | — | — | 1 (2) | 2 (4) | — | — | | Stomatitis/mucositis (%) | 2 (20) | — | — | — | 12 (27) | — | — | — | | Asthenia (%) | 4 (40) | 5 (50) | — | — | 30 (67) | 5 (11) | — | — | | Hypertension (%) | 1 (10) | — | — | — | 1 (2) | — | — | — | | Hypotension (%) | — | — | — | — | — | — | — | — | | Gengival recession/gengivitis (%) | — | — | — | — | — | — | — | — | | Rhinitis (%) | 1 (10) | — | — | — | 1 (2) | — | — | — | | Epistaxis (%) | — | 2 (20) | — | — | 2 (4) | 2 (4) | — | — | | HFS (%) | — | 1 (10) | — | — | 3 (7) | 1 (2) | — | — | | Hyponatriemia (%) | 2 (20) | — | — | — | 2 (4) | — | — | — | | Hypertransaminasemy (%) | 3 (30) | 1 (10) | 2 (20) | 2 (20) | 14 (31) | 13 (29) | 2 (4) | 1 (4) | | Hyperbilirubinemia (%) | 4 (40) | 3 (30) | 1 (10) | — | 17 (38) | 5 (11) | 4 (9) | — | | Cholestasis (%) | 2 (20) | 1 (10) | 1 (10) | — | 12 (27) | 11 (24) | 14 (31) | 1 (2) | | Hyperammoniemia (%) | 3 (30) | — | — | — | 5 (11) | — | 2 (4) | — | | Hypercreatininemia (%) | 2 (20) | — | 2 (20) | — | — | — | — | — | | Hypothyroidism (%) | — | 2 (20) | — | — | — | 2 (4) | — | — | | Anemia (%) | — | — | — | — | — | — | — | — | | Leucopenia (%) | 2 (20) | 1 (10) | — | — | 5 (11) | 1 (2) | — | — | | Neutropenia (%) | — | 1 (10) | — | — | 2 (4) | 1 (2) | — | — | | Thrombocytopeny (%) | 4 (40) | 2 (20) | — | — | 8 (18) | 6 (13) | — | — |
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