First Trimester Biomarkers in the Prediction of Later Pregnancy Complications

Table 2

Summary of first trimester multiparametric tests for later pregnancy complications.

Complication	Author	Biomarkers	Detection rate	False positive rate
Preeclampsia	Poon et al., 2009 [8]	MF, MAP, UtA PI, PlGF, and PAPP-A	93%	5%
	Park et al., 2013 [9]	MF, MAP, UtA PI, and PAPP-A	91.7%	10%
	Scazzocchio et al., 2013 [10]	MF, MAP, UtA PI, PAPP-A, and free 𝛽hCG	80.8%	10%
Preterm birth	Greco et al., 2012 [11]	MF, CRL, and cervical length	54.8%	10%
Gestational diabetes	Maged et al., 2013 [12]	SHBG and CRP	74%	24%
	Nanda et al., 2011 [13]	MF, adiponectin, and SHBG	74.1%	20%
Fetal growth restriction	Karagiannis et al., 2011 [14]	MF, NT, PAPP-A, free 𝛽hCG, MAP, UtA PI, PlGF, PP13, and ADAM12	73%	10%
	Poon et al., 2013 [15]	MF, UtA PI, MAP, PAPP-A, and PlGF	55.5%	10.9%

MF: maternal factors; MAP: mean arterial pressure: UtA PI: uterine artery Doppler pulsatility index; PlGF: placental growth factor; PAPP-A: pregnancy-associated plasma protein A; 𝛽hCG: beta human chorionic gonadotrophin; CRL: fetal crown-rump length; SHBG: sex hormone binding globulin; CRP: C-reactive protein; NT: fetal nuchal translucency; PP13: placental protein 13; ADAM12: A disintegrin and metalloprotease.